A one-stop solution with omnidirectional and up-to-date information on the evolving targeted protein degradation landscape
Custom Degrader Databases and Services to help capitalize the Targeted Protein Degradation way of drug discovery and development
Selective degradation of pathogenic proteins is a promising strategy to drug ‘undruggable’ targets.
Only a fraction of the proteins encoded by the human genome are druggable. The exploration of the undruggable protein landscape has become an attractive strategy by utilizing the emerging field of targeted protein degradation. This technique modulates the target expression by hijacking the intracellular proteolysis machinery. Despite the immense therapeutic potential, this strategy presents several challenges which need to be surmounted to exploit its full capability
Excelra has developed databases and services that could facilitate informed decision making and increase the efficiency of companies looking to develop programs in the targeted protein degradation space
Degraders Intelligence Database (DID)
An intelligence database allowing its users to capture a snapshot of the competitive landscape in the degrader space to understand the companies working in the area and the strategies leveraged by them. This also helps identify potential gaps in the space that could be opportunities for new entrants in the market
Degraders Discovery Database (D3)
An indispensable resource for designing degraders and expanding services into new therapeutic areas. It helps overcome challenges in the TPD space pertaining to the congruence of targets with ubiquitination machinery, expanding the exploratory scope of E3 ligases, and gaining deeper insights into the compound-related parameters for TPD.
Targeted Protein Degradation Services
Our Targeted Protein Degradation Services enable the development of differentiated therapies by leveraging our manifold experience in studying the TPD space and utilizing our data assets as per the custom client requirements.
Excelra’s proprietary offerings in the TPD space are fuelled by our capabilities and 18+ years of experience in data collection, data curation and data annotation for our clients. Our substantial domain expertise in this area helps us in understanding the best approach for answering the problem statements of our clients.