Unlock the power of data
Data is emerging as the new currency which will transform the way businesses operate. But what use is data if it’s not understood and utilised in the right ways? Our data scientists can help you see how different data sets interact. Having your data sets in an understandable format will enhance your digital transformation journeys.
You need robust data services via the cloud. You need to harness computer vision and natural language processing with AI and ML to improve decision-making and accelerate innovation. For this you need to understand insights from the abundance of available data.
We provide data science services that accelerate the identification of promising compounds and targets helping you increase accuracy and in parallel reduce your R&D expenditure.
Our data scientists analyze, visualize, and model large amounts of data to meet your research goals. We incorporate five phases to maximize data harnessing:
Exploration and confirmation, predictive analysis, regression, text mining, and qualitative analysis. This is the functional core of data science. We interrogate and analyze your data to suit your requirements and objectives.
Data reporting, data visualization for life science, business intelligence, and decision-making. In this final step, we prepare the results in the form of charts, graphics, and visual reports to summarize and further support your ongoing drug design and development journey.
HIT calling algorithm on DEL selection data
The client’s objective was to identify unique binders to the pool of target proteins via a functional HIT-calling algorithm on DNA-encoded library (DEL) selection data. Due to the compounds’ library size (in millions), the client required a pragmatic statistical method to reliably detect target-specific enrichment.
We started with a detailed analysis of the low read count data generated from the Next-generation sequencing (NGS) processing pipeline. We chose an appropriate normalization algorithm to mitigate the risk of selecting false positives or dropping false negatives, and we applied differentially expressed genes (DEG) concepts based on the contrast sheet. The pipeline was built to be scalable and could be used for identifying binders or non (weak) binders. For additional accuracy, we even implemented notions stemming from the chemical structure space.
Our work with the client produced a fully functional automated pipeline that identified true hits from DNA-encoded library (DEL) selection output data, even in cases where the raw number count is low.
Led by science, driven by data
We’re an agile, cross-functional team of computational biologists, biologists, pharmacologists, data architects, bioinformaticians and medicinal chemists. We’re tech natives and understand the power of data in the discovery of drug development value chain.
A partner that can scale to your needs
We’re the partner of choice for leading global pharmaceutical and biotechnology companies, working with the top 16 pharma companies in the world.