Our client’s requirement
The client worked in the area of in-silico sensitivity and specificity analysis of probes and primers for SARS-CoV2 molecular diagnostic assays. They aimed to obtain the tabular output of gene variants and in-depth variant prevalence information from non-redundant and filtered sequence alignments. This requirement aligned closely with their broader goals of leveraging Bioinformatics Solutions to enhance accuracy in assay development and Scientific Informatics to streamline molecular diagnostics research.
Our approach
We implemented the following key activities to accelerate the development of the rapid detection NAAT assay:
- Retrieved the SARS-CoV2 multiple sequence alignment from reliable sources such as Nextstrain/GenBank.
- Conducted an in-depth analysis of the prevalence of each variant in the two genes of interest.
- Developed a workflow explicitly tailored for extracting two specified gene sequences.
By applying our expertise in Computational Biology and data-driven approaches, we ensured high-quality outcomes in molecular diagnostics. Our curated workflow empowered the client to achieve efficiency gains and actionable insights, reducing the time-to-market for novel diagnostic assays.
For similar success stories, explore more of our Case Studies on scientific data management, precision medicine, and genomics.
