Our client’s requirement
Our client, a prominent player in the Biotech industry based in the EU, collaborated with Excelra
for a transformative initiative to reanalyze their database for siRNA targets.
Their objectives included:
- Meticulous identification and selection of siRNA on/off-targets
- In-depth pathway and network analysis
- Integration of insights with toxicity screening data
The goal was to gain comprehensive knowledge of molecular pathways and potential therapeutic targets, aligning with Excelra’s expertise in bioinformatics solutions.
Our approach
Our strategy revolved around conducting precise siRNA hit calling and discerning on/off-target interactions. We meticulously curated a selection of siRNA candidates for subsequent toxicity screening, defining crucial thresholds for cell viability, toxicity, and household gene stability.
This approach provided detailed insights into the complexities of siRNA interactions, enabling refined therapeutic target selection. By integrating computational biology services and pathway/network analysis, we delivered a data-driven framework to advance drug discovery and genomic research.
For more insights, explore our related case studies:
