Our client’s requirement
Our client, a Partner Research Organization based in Europe, partnered with Excelra
to explore novel therapeutic targets by characterizing diverse microglia phenotypes. The objective was to identify potential therapeutic targets within these specialized cells, enabling advancements in neurological interventions. Emphasis was placed on discovering subtle traits and understanding microglia diversity for innovative treatments.
Our approach
Excelra synthesized data from six public single-cell RNA sequencing datasets. Using advanced clustering and annotation methodologies, we systematically identified various microglia phenotypes.
- Marker gene identification enabled precise differentiation of microglia subtypes.
- Differential gene expression analysis allowed characterization of unique phenotypic traits.
- This comprehensive approach uncovered previously unknown facets of microglia diversity, supporting the discovery of novel therapeutic targets.
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