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Influence of Dapagliflozin Dosing on Low-Density Lipoprotein Cholesterol in Type 2 Diabetes Mellitus: A Systematic Literature Review and Meta-Analysis

By August 8, 2024No Comments

This groundbreaking publication, featured in The Journal of Clinical Pharmacology, was co-authored by researchers, including Srinivas Martha from Excelra Knowledge Solutions Pvt. Ltd.,

delves into the effects of dapagliflozin, a medication used to treat type 2 diabetes, on LDL cholesterol levels.

Here’s why this research is important:

  • Millions of people worldwide are affected by type 2 diabetes.
  • Dapagliflozin is a medication used to manage blood sugar levels in these patients.
  • While effective, dapagliflozin may increase LDL cholesterol, a risk factor for heart disease.

The research conducted a systematic review and meta-analysis to understand:

  • How dapagliflozin affects LDL cholesterol levels.
  • Whether this increase in LDL cholesterol translates to a higher risk of adverse cardiac events.
  • The impact of dapagliflozin on blood sugar control.

The findings suggest:

  • Dapagliflozin does increase LDL cholesterol, especially at the higher 10mg dose.
  • However, this increase is considered to be minimal and may not significantly raise cardiovascular risks.
  • Dapagliflozin effectively lowers blood sugar levels, both as a standalone treatment and when combined with other medications.

To learn more about this crucial research and its implications for type 2 diabetes management, click the link below to access the full publication in the Journal of Clinical Pharmacology

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Note: No part of this report may be reproduced or distributed without prior written permission.

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